Day One Biopharmaceuticals Inc. (NASDAQ:DAWN)

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  • Lou: Couldn't help it - decided that I wanted another Biotech. Added $DAWN - new position for me.
  • woodman: @Lou $DAWN - It does look interesting, Lou. It's on my list, but I've not gotten to it in depth. I did see it has a PDUFA on 4/30 for its brain cancer med. that could really make it pop ... or sink. I have to research it more, but y biotech $$ are fully deployed, and I don't want to sell any bios I already have to add another at this time. I'm still trying to move things around to add to what I already have. But let us know what you find out. Thanks.
  • Lou: @woodman $DAWN - just a relatively small starter, strictly on the basis of price action.
  • woodman: $DAWN - severe pullback in this one, but seems to be basing. Would like to see sustained closes above 8dEMA and see the 5dEMA get up through it and the 13dEMA. This is a biotech working on pediatric brain cancer and solid tumors therapies. It is going to present here on its solid tumor/melanoma candidate. Maybe get a run higher out of this into the event? It seems oversold. I haven't been able to detect the reason for the big sell-off. Anyway, here's the event announcement. https://ir.dayonebio.com/news-releases/news-release-details/day-one-announces-upcoming-presentation-19th-european/
  • woodman: $DAWN - Apparently, the drop in the stock may be due to a misunderstanding in the Market that the company changed endpoints for its pediatric brain cancer therapy. I believe it has data and a pre-NDA meeting with the FDA coming this Q. I need to do more research.
  • bhaden1: $DAWN @woodman Moving today. "Smart Money" buying the pull back? Have a starter position at 13.25. Long.
  • sierramp: @woodman $ARDX $ETNB $PDSB $AMLX $ORMP $VKTX $DAWN $BMRN $CPRX $NWBO $SRPT $VRTX $XFOR #Biotech Thank you for this. Can't buy them using my usual process for evaluation but very, very interesting so attempting to come up with another way to evaluate. If you have time, would you share how they pass your test?
  • woodman: @sierramp $ARDX $ETNB $PDSB $AMLX $ORMP $VKTX $DAWN $BMRN $CPRX $NWBO $SRPT $VRTX $XFOR #Biotech - Catalysts (trial data due; FDA decisions due, etc.), important therapeutic areas and potential moats, interesting combos with established companies and institutions, strong interest by people I respect. Not all of these necessarily apply to each and every one, but some of these elements apply to each. Not an exhaustive list, but what instantly came to mind. Fwiw, I provided a small bit of color on most of these in a prior recent post here that you can search for. The chart is a factor, but to a more limited extent - less so than my ordinary trading MO.
  • pperlroth: @woodman $ARDX $ETNB $PDSB $AMLX $ORMP $VKTX $DAWN $BMRN $CPRX $NWBO $SRPT $VRTX $XFOR #Biotech These are great! Thank you for sharing as I often look to this industry as the payouts can be massive given potential takeovers AND potential FDA approvals for new drugs/therapies.
  • woodman: $DAWN - at bottom of channel. Barely holding on. But not a bad place to start a position - low risk on the chart - if interested in this as a potentially big catalyst trade (trial data) for 1Q2023 for its pediatric brain cancer drug. That said, any sudden reporting of data will send it much higher or much lower. But as a catalyst, it could start to move higher into the event. Biotechs are always risky, however. I am long.
  • woodman: Updated list of #Biotech that I'm currently in ($$ amounts vary; not in any particular order): $ARDX $ETNB $PDSB $AMLX $ORMP $VKTX $DAWN $BMRN $CPRX $NWBO $SRPT $VRTX $XFOR (bought today).
  • woodman: Current #biotech and Big #Pharma that I'm in: $ARDX (gift drop 2 days ago; catalyst with news likely in January - see my prior posts) $CPRX (keeps going) $ORMP (strong today; catalyst into January for P3 results for oral insulin; also, CEO just talke ...
  • woodman: $DAWN continues up off the bottom of the channel. Yesterday must have shaken out a lot of people. I closed my eyes and added when it started to bounce.
  • woodman: $DAWN - this one is working on an early stage pediatric brain cancer drug in a therapeutic area that needs something. It closed back in the channel today, on a long hammer/doji after it fell out of channel rather vigorously at open which I thought was a strange thing on no news that I found. I added at 18.95 when it was rebounding. Once it go back above VWAP it never looked back. We'll see if this is a shot across the bow or a great save and continuing upward channel.
  • Docoof: @woodman $DAWN (Fwiw) BofA, 12/1: Out of darkness, into the $DAWN with solutions from Day One; Initiate Buy — Initiating Coverage: BUY | PT :34.00 USD | Price: 21.23 USD —Tovorafenib presents a better option than SOC in pLGG— Lead candidate, tovorafenib, is potentially a game-changer in pLGG, which can replace the current SOC consisting of mostly chemo, radiation, and invasive surgery, which while acceptable in efficacy, has long-term toxicity/health burdens on patients. That said, tovorafenib, in our view, provides a solution that minimizes toxicity while also exhibiting superior tumor control (64% ORR, 91% clinical benefit rate). Together, our SOTP NPV analysis yields a PO of $34/sh on what we would consider to be conservative estimates. We initiate coverage of Day One with a Buy rating.
  • woodman: @Docoof $DAWN - Thanks! These biotechs are always risky. Top line data for Firefly 1 is due 1Q23. Results to date have been good. Should be a top catalyst.
  • woodman: $DAWN nearing bottom of rising channel (drawn from Sept 23). This has had decent, reliable swings from bottom to top - see 9/23, 10/18, 11/4-9. 11/30 was another swing low area but didn't make it all the way down to channel bottom.
  • MongosPawn: @woodman $DAWN Been tracking this one closely. Very tempting here. Love the channel trade in this market. May start a position tomorrow depending . . .
  • woodman: $DAWN - One for the radar. Base-building. It broke out above the 50 day and then out of the base last week and has pulled back to hold the 50d back within the base at the top of its range. Could be readying for another move higher. I've started a smallish position. (Other ways to look at it if looking at the weekly. Watch and react.)
  • woodman: $DAWN catalyst trade taking effect as it rises out of consolidation and above 50d. I started a small position yesterday and added small this morning. https://ir.dayonebio.com/news-releases/news-release-details/day-one-announces-positive-initial-data-pivotal-firefly-1-trial
  • woodman: $DAWN worth keeping an eye on. Testing top of ~2 month base/range which is the right shoulder looking further out. It has a brain cancer drug candidate. Full updates expected in 2023. A move above 21.58 could get it moving well.
  • Justhanging48: @woodman $DAWN Looks like a day 3 top for now, but will keep on the watch list
  • woodman: @Justhanging48 $DAWN - No position currently. Watching it.
  • woodman: $DAWN - Flag after big move yesterday. Still in this. 5-8dEMA support intact.
  • woodman: $DAWN - One I mentioned on 6/13 when it gapped up on good early trial results for its pediatric brain cancer drug. Since then, it's continued up. 5-8dEMA support thus far.
  • vcondry: @woodman $DAWN been following this one since your mention...great pick!
  • vcondry: anyone else still in $DAWN been on a climb since the announcement several days ago...another member in here had pointed them out. I bought it on the climb...missed the gap up and still up about 10% from first buy
  • woodman: $DAWN - spec biotech with some interesting early trial results for a pediatric brain cancer drug. No position currently but rooting for it! https://ir.dayonebio.com/news-releases/news-release-details/day-one-announces-positive-initial-data-pivotal-firefly-1-trial
  • vcondry: @woodman $DAWN WOW... I hope the gap up is reflective of its true potential!
  • woodman: @vcondry $DAWN - Need to analyze the market potential for this. If it's safe and there being no other treatment, it could end up getting fast-tracked for approval.
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Stock Price $17.17
Change -2.28%
Volume 1,163,420

Day One Biopharmaceuticals Inc is a clinical-stage biopharmaceutical company. It is dedicated towards developing and commercializing targeted therapies for patients of all ages with genetically defined cancers. Initially, it focuses on clinical development efforts on pediatric patients living with cancer, a vulnerable population that has been underserved in the recent revolution in targeted therapeutics and immuno-oncology. The lead product candidate, DAY101, is an oral, brain-penetrant, highly-selective type II pan-rapidly accelerated fibrosarcoma, or pan-RAF, kinase inhibitor.

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